CSIR-UGC National Eligibility Test (NET) for Junior Research Fellowship and Lecturer-ship
Some Important Questions Collected from the Memory of Students and Probable Questions and Answers
Previous and Probable (Memory based) Qustions & Answers Paper-1 Part-B June 2010
c. Fungus d. Bacteria
Expln. – G6PD deficiency is an X-linked recessive hereditary disease characterized by low levels of glucose-6-phosphate dehydrogenase which is involved in HMP pathway. G6PD catalyzes the oxidation of Glucose-6-phosphate to 6-phosphogluconolactone. This shunt generates NADH and as a result reduced glutathione(GSH) is produced which is necessary for the reduction of H2O2. Hydrogen peroxide is a strong oxidant that will degrade the RBC and cause hemolysis if it is not reduced.
When a plasmodium enter the RBC, it oxidizes NADPH from the HMP pathway for its metabolism. Thus reduced glutathione(GSH) is not produced. Deficiency of GSH is more severe in G6PD deficient individuals, leading to peroxide-induced hemolysis which curtails the development of plasmodium.
Note: Relation between Favism and G6PD – see the simple instant notes.
1. Viral resistance 2. Seed setting
3. Fruit ripening 4.Herbicide resistance
Ans – 3
1. Anti-apoptic and pro-apoptic 2. Pro-apoptic and anti-apoptic
3. Both pro-apoptic 4. Both anti-apoptic
Ans- 1 Expln. : Bcl-2(B-cell lymphoma 2) is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene. These proteins govern mitochondrial outer membrane permeabilization and can be either pro-apoptotic (Bax, BAD, etc) or anti-apoptotic (Bcl-2 proper). Bax (Bcl-2 associated x protein) is thus a protein of the Bcl2 gene family.
1. Breast 2. Oral
3. Prostrate 4. Lung
More Questions & Answers Refer Instant Notes